Efficacy of Continuous Chelation With Etidronate And Sequential Chelation With Chitosan On Bacterial Reduction In Teeth With Pulp Necrosis: A Double-Blind, Randomized Clinical Trial

All three irrigation protocols, including continuous chelation with etidronate, sequential chelation with chitosan, and traditional chelation with EDTA, significantly reduced bacterial levels in teeth with primary endodontic infections.Etidronate and chitosan may serve as alternatives to EDTA; however, further prospective clinical studies are required to validate and recommend their use in clinical practice.(EEJ-2025-07-114).