A new water-soluble Ni( <scp>ii</scp> ) complex as a prototype of metallodrugs to treat toxoplasmosis

The Ni( ii ) compound showed higher activity (IC 50 = 380 nM) on T. gondii than sulfadiazine and was nontoxic to the host cell (selective index &gt; 1800). TEM studies showed that the compound induces deformation in the parasite's conoid structure.

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Publication Details

Journal
Inorganic Chemistry Frontiers
Published
2025-12-04
DOI
https://doi.org/10.1039/d5qi02078f
Primary Topic
Toxoplasma gondii Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

A new water-soluble Ni( ii ) complex as a prototype of metallodrugs to treat toxoplasmosis

Inorganic Chemistry Frontiers
Toxoplasma gondii Research Studies
article

A new water-soluble Ni( ii ) complex as a prototype of metallodrugs to treat toxoplasmosis

article en

Abstract

The Ni( ii ) compound showed higher activity (IC 50 = 380 nM) on T. gondii than sulfadiazine and was nontoxic to the host cell (selective index &gt; 1800). TEM studies showed that the compound induces deformation in the parasite's conoid structure.

Inorganic Chemistry FrontiersVol. 13(4)
Instituto Federal Fluminense (BR), State University of Norte Fluminense (BR), Universidade Federal de Santa Catarina (BR)
Clean water and sanitation
Openalex Percentile: Top 36%
Toxoplasma gondii Research Studies
DOISourceOpenAlex
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A new water-soluble Ni( <scp>ii</scp> ) complex as a prototype of metallodrugs to treat toxoplasmosis · Inorganic Chemistry Frontiers (2025) | TGRS Research Map | TGRS