FUNCTIONAL CONDITIONS OF THE LIVER IN PATIENTS WITH STAGE FIVE CHRONIC KIDNEY DISEASE ON RENAL REPLACEMENT THERAPY BY HEMODIALYSIS

The condition of the liver in patients with stage 5 chronic kidney disease (CKD), especially those on hemodialysis, is a signi†cant medical problem. Impaired kidney function leads to increased stress on the liver, which can cause liver damage. The article discusses the main liver pathologies, such as fatty degeneration, †brosis, and cirrhosis, and connection with CKD and hemodialysis. The article reviews scienti†c literature on liver pathologies in patients with CKD. Data from clinical studies, meta-analyses, and experimental work were used to examine the mechanisms of the toxic e—ects of dialysis solution components on the liver. Studies have shown that patients with stage 5 CKD on hemodialysis often develop fatty liver disease, †brosis, and cirrhosis. The main causes are metabolic disorders, toxin accumulation, and the toxic e—ects of dialysis solution components. It has also been found that hemodialysis can lead to vitamin and mineral de†ciencies, which worsen liver condition. The relationship between liver and kidney function requires a comprehensive approach to treatment. It is important to promptly detect changes in liver condition and adjust therapy to prevent disease progression. Special attention should be paid to managing risk factors such as hyperglycemia, arterial hypertension, and dyslipidemia. The condition of the liver in patients with stage 5 CKD requires special attention. A comprehensive treatment approach, including monitoring liver and kidney function, can signi†cantly improve patients’ quality of life and prevent the development of severe complications. The literature was reviewed for the period from 2017 to 2024 using the websites Pubmed, Springer, eLibrary both Russian and English.