Cholesterol pericarditis associated with rheumatoid arthritis: A case report and review of literature

Cholesterol pericarditis is a rare disease characterized by the presence of chronic massive cholesterol pericardial effusion, with or without cholesterol crystals. The pathogenesis of cholesterol pericarditis remains unclear. A 64-year-old male presented with a one-year history of vomiting and chest tightness, along with a recurrent episode within the last 10 hours. He had a medical history of chronic pericardial effusion. Upon admission, he was diagnosed with rheumatoid arthritis, and imaging revealed massive pericardial effusion. The analysis of the pericardial fluid demonstrated an abundance of cholesterol crystals. After undergoing pericardiocentesis drainage, the patient's symptoms improved, and he was subsequently discharged from hospital. Our case report aims to enhance the comprehension of cholesterol pericarditis in clinical practice by providing a comprehensive analysis of pericardial effusion characteristics and laboratory findings in a patient with rheumatoid arthritis. Further studies are required to investigate the etiology, pathogenesis, as well as early diagnosis and treatment strategies for cholesterol pericarditis.

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Publication Details

Journal
Heliyon
Published
2025-11-29
DOI
https://doi.org/10.1016/j.heliyon.2025.e44290
Primary Topic
Pericarditis and Cardiac Tamponade
Type
article
Field-Weighted Citation Impact
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article

Cholesterol pericarditis associated with rheumatoid arthritis: A case report and review of literature

Heliyon
Pericarditis and Cardiac Tamponade
article

Cholesterol pericarditis associated with rheumatoid arthritis: A case report and review of literature

article en

Abstract

Cholesterol pericarditis is a rare disease characterized by the presence of chronic massive cholesterol pericardial effusion, with or without cholesterol crystals. The pathogenesis of cholesterol pericarditis remains unclear. A 64-year-old male presented with a one-year history of vomiting and chest tightness, along with a recurrent episode within the last 10 hours. He had a medical history of chronic pericardial effusion. Upon admission, he was diagnosed with rheumatoid arthritis, and imaging revealed massive pericardial effusion. The analysis of the pericardial fluid demonstrated an abundance of cholesterol crystals. After undergoing pericardiocentesis drainage, the patient's symptoms improved, and he was subsequently discharged from hospital. Our case report aims to enhance the comprehension of cholesterol pericarditis in clinical practice by providing a comprehensive analysis of pericardial effusion characteristics and laboratory findings in a patient with rheumatoid arthritis. Further studies are required to investigate the etiology, pathogenesis, as well as early diagnosis and treatment strategies for cholesterol pericarditis.

HeliyonVol. 12(1)
Zhejiang Chinese Medical University (CN), Westlake University (CN), Second People 's Hospital of Jinzhong (CN), Hangzhou Women’s Hospital (CN), Yanbian University Hospital (CN), First People's Hospital of Nanning (CN), Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Good health and well-being
Openalex Percentile: Top 34%
Pericarditis and Cardiac Tamponade
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Cholesterol pericarditis associated with rheumatoid arthritis: A case report and review of literature · Heliyon (2025) | TGRS Research Map | TGRS