Recent Advances in Catalytic Hydroamidation Reactions of Unsaturated Substrates with Dioxazolones

Abstract Transition metal–catalyzed hydroamidation of alkenes and alkynes represents an efficient method for synthesizing structurally diverse amides, which are ubiquitously found in natural products, bioactive molecules, and pharmaceutical agents. In this context, dioxazolones have attracted extensive research attention as readily accessible and reactive amidating reagents. Herein, we summarize the advancements in hydroamidation reactions of alkenes and alkynes with dioxazolones, categorizing them according to the reaction mechanisms and classifying each section by the type of metal catalysts employed. We provide a comprehensive discussion of the scope and limitations, proposed mechanisms, and the opportunities for future development.