Synthesis of Modified Fusicoccane Diterpenoids via Diverging MHAT Reactivity

Cotylenin and fusicoccin diterpene glycosides modulate the stability of 14-3-3 protein-client interactions. Here, we report the divergent syntheses of representative aglycons, brassicicene (BR-I), and talarmalnoid B (Tal-B) by modification of Studer's Mukaiyama hydration variant.

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Publication Details

Journal
Synthesis
Published
2025-11-27
DOI
https://doi.org/10.1055/a-2744-6756
Primary Topic
14-3-3 protein interactions
Type
article
Field-Weighted Citation Impact
0.00
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article

Synthesis of Modified Fusicoccane Diterpenoids via Diverging MHAT Reactivity

Synthesis
14-3-3 protein interactions
article

Synthesis of Modified Fusicoccane Diterpenoids via Diverging MHAT Reactivity

article en

Abstract

Cotylenin and fusicoccin diterpene glycosides modulate the stability of 14-3-3 protein-client interactions. Here, we report the divergent syntheses of representative aglycons, brassicicene (BR-I), and talarmalnoid B (Tal-B) by modification of Studer's Mukaiyama hydration variant.

SynthesisVol. 58(05)
Scripps Research Institute (US), Scripps Health (US)
Openalex Percentile: Top 42%
14-3-3 protein interactions
DOIOpen Access PDFOpenAlex
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Synthesis of Modified Fusicoccane Diterpenoids via Diverging MHAT Reactivity · Synthesis (2025) | TGRS Research Map | TGRS