TO DESIGN AND CHARACTERIZATION OF HERBAL OINTMENT BY USING MARTYNIA ANNUA, GOSSYPIUM HERBACEUM WITH OTHER POLYHERBS FOR ITS WOUND HEALING POTENCY

ABSTRACT Wound healing is one of the most complex processes in the human body. It involves the spatial and temporal synchronization of a variety of cell types with distinct roles in the phases of haemostasis, inflammation, growth, re-epithelialization, and remodelling. With the evolution of single cell technologies, it has been possible to uncover phenotypic and functional heterogeneity within several of these cell types. There have also been discoveries of rare, stem cell subsets within the skin, which are unipotent in the uninjured state, but become multipotent following skin injury. Unravelling the roles of each of these cell types and their interactions with each other is important in understanding the mechanisms of normal wound closure. Changes in the microenvironment including alteration in mechanical forces, oxygen levels, chemokines, extracellular matrix and growth factor synthesis directly impact cellular recruitment and activation, leading to impaired states of wound healing. In conclusion. Wound healing is a multiphase process involving well- calibrated and synchronized responses to an injury to the skin.