Modular de- and re-construction of vascularized osteochondral tissues in an Organ-on-Chip dual-compartment platform

This modular Organ-on-Chip platform offers a physiologically relevant and experimentally accessible model of the vascularized osteochondral interface, enabling systematic dissection of cell-specific roles in joint homeostasis and inflammation. By recapitulating key features of early osteoarthritic pathology-including barrier breakdown, stromal invasion, and endothelial remodeling- with a highly modular and technologically robust approach, this system holds translational promise for preclinical testing of disease-modifying OA therapies, biomarker discovery, and regenerative strategies targeting cartilage-bone crosstalk.