Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults.

Using a large, community-based cohort, we demonstrate that non-linear alterations in functional connectivity occur in specific networks even during the asymptomatic phase of AD. Moreover, Aβ-related network connectivity is cognitively relevant, highlighting functional brain networks as promising imaging markers for early detection and prognosis of AD.