Comparative analysis of platelet counts using Beckman Coulter DxH-900, Mindray BC-6800 Plus, CellaVision DM9600 and the flow cytometry reference method: addressing the challenge of giant platelets

These findings highlight the analytical limitations of routine technologies in challenging samples and emphasize the importance of method selection for accurate platelet reporting. A correction factor for optical counts and the integration of digital morphology could enhance diagnostic reliability in cases involving giant platelets.