The loss of efficacy of fluoxetine in pediatric depression: explanations, lack of acknowledgment, and implications for other treatments

The seeming lack of clinically meaningful efficacy of fluoxetine for the treatment of pediatric depression needs to be considered by those who develop treatment recommendations as well as by patients and clinicians. The biases we observed are not only relevant in the evaluation of fluoxetine and other antidepressants for pediatric depression, but also for any new treatment.