Effect of Conductive Polymer, Magnetic Nanoparticles and Simvastatin Drug on Bone Regenaration in 3D Scaffolds Based on PGAZ-co-PEG1000 and PLA

In this study, new 3D scaffolds based on synthesized PGAZ-co-PEG1000 and PLA were prepared by salt leaching technique and Polythiophene as conductive pairs and Fe2O3 as magnetic nanoparticles, were also added to the 3D scaffolds. The FTIR test revealed that there is a relatively good interaction between the components used in these scaffolds. The XRD test also showed that the simultaneous presence of nanoparticles Fe2O3 and Polythiophene has a reducing effect on the crystal structure of the samples. SEM analysis also showed that suitable three-dimensional structures were formed within the samples and that the presence of other components in the scaffolds had significant effects on the three-dimensional structures of the scaffolds. The mechanical behavior of the samples in compression mode was analyzed in both dry and wet states. Young's modulus in dry and wet states showed completely different behavior among the samples. The compressive strength of the nanocomposite sample, which has twice the amount of nanoparticles as Polythiophene, was higher in both wet and dry states than in all the samples. Also, the degradation test was investigated in two acidic and basic pH, and interesting results were obtained. Alizarin red, H&E, and cell adhesion tests were performed on simple samples and samples loaded with the drug, and the results showed that the presence of Polythiophene and nanoparticles have a good effect on cell growth and proliferation, and Simvastatin drug has also demonstrated sound effects in addition to these substances.