Supratentorial ependymoma with giant cells of the corpus callosum: A case report

• Supratentorial ependymomas with giant cells are extremely rare. • 8-year-old child with recurrence in ten months of initial diagnosis. • Rare neoplasm involving the corpus callosum. • Poor response to radiation therapy corresponds to the aggressive nature of the lesion. Ependymomas involving the corpus callosum are relatively rare tumours of the central nervous system which poses diagnostic and therapeutic challenge to the treating clinician. Ependymomas with presence of giant cells are uncommon histological findings. Here we present an interesting case of an 8-year-old male child with a space occupying lesion arising from the body of the corpus callous on the left side, which was diagnosed as Supratentorial ependymoma Grade 3 by histopathology and immunohistochemistry on initial biopsy after considering the differential diagnosis of other lesions of the central nervous system with similar histomorphology. The patient received radiation therapy, however lesion recurred within a period of 10 months. Subsequently histopathology revealed the presence of predominantly numerous highly pleomorphic bizarre cells and multinucleate giant cells arranged in sheets having brisk mitosis (15/10HPF) with adjacent areas of necrosis and haemorrhage, implying the aggressive nature of the lesion.