Evaluation of Nickel nanoparticles as a potential antifungal agent against T. tonsurans

The present study main goal is to assess the in vitro antifungal activity of nickel nanoparticles (NiNPs) against some species of Trichophyton causing dermatophytosis infections. Specimens were taken and the identification of the fungi was determined by their macroscopic and microscopic features. The predominant species was T. tonsurans. The nickel nanoparticles at various levels of concentrations (200–300 µg/ml) were used for the evaluation through OD600. A concentration of 225 µg/ml was determined as the minimum inhibitory concentration (MIC), while 250–300 µg/ml was fungicidal (MFC). Statistical analysis (ANOVA) revealed highly significant differences between concentrations tested (p < 0.05). These results reveal the potential of using nanoparticles as an alternative or complementary therapeutic in antifungal resistance.