SCOPOLETIN REDUCES FAT ACCUMULATION IN CAENORHABDITIS ELEGANS

Scopoletin, a naturally occurring coumarin, has been associated with the regulation of lipid metabolism. In this study, we used Caenorhabditis elegans, a well established in vivo nematode model, to explore the role of scopoletin in fat accumulation. C. elegans treated with scopoletin (200 µM) exhibited significantly reduced triglyceride levels compared to the control, without significantly affecting food intake or locomotive activity in wild type C. elegans. The reduction in fat accumulation by scopoletin suggests that scopoletin may regulate lipid metabolism independently of food intake and energy expenditure. Further investigation of the underlying molecular mechanisms is required to determine whether scopoletin modulates lipid metabolism through specific genetic pathways.