Exploring Left Ventricle Dimensions and Interventricular Septum Thickness in the Iranian Population: A Comparative Analysis through ECG Gated, CT Angiography and Echocardiography

Background: Cardiovascular diseases (CVDs) are a significant cause of morbidity and mortality worldwide, particularly among the Iranian population. Assessing left ventricular (LV) dimensions and interventricular septum (IVS) thickness is crucial in diagnosing and managing various cardiac conditions. This study aimed to compare LV dimensions and IVS thickness using electrocardiogram (ECG) gated computed tomography angiography (CTA) and echocardiography. Methods: A cross-sectional study was conducted on 160 Iranian individuals without known CVD from March to September 2023 in Hospital, Tabriz, Iran. Participants underwent both ECG-gated CTA and echocardiography for assessment of LV dimensions and IVS thickness. Measurements were performed by experienced radiologists and cardiologists, respectively. Echocardiography and CTA were analyzed for their correlation using Pearson's correlation coefficient. Statistical analysis was conducted using SPSS V25 software. Results: The study revealed a significant correlation between various LV dimensions and wall thickness measurements obtained from echocardiography and CTA (p<0.000). Strong and significant correlations were found in measurements taken from different views and regions of the heart, including the parasternal long-axis (PLAX) view, Mid and Base views, and the anteroseptal and inferoseptal regions (p<0.000). Echocardiography measurements also showed significant correlations, with varying strengths. Conclusion: The comparative analysis of LV dimensions and IVS thickness using ECG-gated CTA and echocardiography demonstrated significant correlations, suggesting the potential clinical utility of both imaging techniques in diagnosing and managing CVD in the Iranian population. The 4-chamber and PSAX methods can be used interchangeably to measure interventricular septum thickness. Further research is required to validate and expand upon these results.