The therapeutic efficacy of 1,2,3-triazoles in cancer

The financial and human toll of cancer's global impact cannot be quantified. Unfortunately, the side effects of cancer treatments are often severe. Drug resistance is another issue doctors must address when treating cancer. Other factors that contribute to an increased risk of cancer include alcohol consumption, poor nutrition, water and air pollution, and tobacco use. Derivatives of 1,2,3 triazole and their groups have gained a lot of importance due to their diverse biological activities and their ability to treat cancer. This is evident in the toxic effect of transition metal compounds and heterocyclic compounds in the formation of stable communities, which increases their effect on diverse groups of cancer cells through the direct pharmacological effect on the target cells. This is due to the unique structure of the triazole ring, which allows hydrogen bonds and stacking of π–π in coordination with the metal center. The acyclic part contains nitrogen 1-2-3-triazoles, five groups that perform various therapeutic functions. There are many drugs approved for the treatment of a wide range of cancers that contain 1-2-3-triazoles, in addition to pharmaceutical compounds that are in the clinical research stage. Therefore, the importance of the compound is increasing in the field of cancer research.