Reimagining cytopathology in the molecular era: Integration or fragmentation?

Cytopathology has been embraced for years in diagnostic pathology because of its simple, quick, cost-effective, and minimally invasive technique for diagnostic precision. [1]Almost solely based on morphology, it provides expeditious and minimally invasive diagnostic insights to the pathologists and clinicians.However, the current understanding of disease has accelerated with the evolution of next-generation sequencing, whole exome sequencing, DNA methylation, etc., and placed cytopathology at a crossroads. [2]So, the core question arises: Should cytopathology become an integrated pillar of personalized medicine, or should fragmentation be risked by remaining tied to obsolete paradigms?