SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL ACTIVITY OF SCHIFF BASE DERIVATIVES CONTAINING IMIDAZOLE NUCLEUS

Imidazole is a heterocyclic and a 1,3-diazole, is classified as an alkaloid.[1] Clotrimazole and Miconazole are the two imidazole drugs introduced as topical antimycotics on the market.[2,3] Losartan potassium is a medication that acts as an antihypertensive agent taken orally[4-6] Losartan's synthesis requires 2-butyl-5-chloro-4- formyl-3H-imidazole which is one of its essential intermediates.[7,8] The Schiff base derivatives of (3a-3j) were synthesized by the condensation of Amide derivatives with 3-(hydrazino carbanoyl)-4-methoxybenzenesulfonamide in the presence of glacial acetic acid. The structures of newly synthesized compounds were confirmed based on 1H-NMR, mass spectra, and IR data. All the newly synthesized compounds were screened for their antibacterial activity against Gram +ve Bacteria Bacillus subtilis, Staphylococcus aureus, and Gram –ve Bacteria Escherichia coli, Pseudomonas aeruginosa and Fungi Aspergillus niger.