LIQUISOLID COMPACT TECHNIQUE; A PROMISING APPROACH FOR SOLUBILITY ENHANCEMENT

The solubility of poorly water-soluble drugs remains a critical challenge in pharmaceutical formulation, significantly impacting bioavailability and therapeutic efficacy. With an increasing number of lipophilic drug candidates in development, the need for effective solubility enhancement techniques has become more pressing. This review examines various strategies for enhancing drug solubility, including pH adjustment, complexation, solid dispersion, co-solvency, hot-melt extrusion, Sonocrystallization, solvent evaporation, and micronization. Among these, the liquisolid compact technique has emerged as a promising approach for enhancing the dissolution rate of poorly soluble drugs. This method involves converting liquid medications into dry, free-flowing powders using suitable carrier and coating materials, thereby improving wettability, surface area and aqueous solubility. The mechanisms, advantages, limitations and recent advancements in liquisolid technology are discussed, along with their potential for industrial application. The review also highlights recent studies demonstrating the effectiveness of liquisolid systems in enhancing drug dissolution and bioavailability, positioning them as a viable alternative to conventional formulation techniques.