Neuroendocrine Nutrition: The New Science of Communication Between Nutrients, Hormones, and Neurotransmitters

<div>This work presents the conceptual and scientific foundations of Neuroendocrine Nutrition, an integrative field that connects nutrition, neuroscience, endocrinology, immunology, metabolism, and circadian biology. The manuscript introduces the theoretical basis, clinical applications, and translational perspectives of this emerging discipline, outlining how nutrients function as biochemical signals capable of modulating hormones, neurotransmitters, immune responses, and systemic homeostasis.</div> <div> </div> <div>The paper includes:</div> <div>• Theoretical foundations of the neuroendocrine axes (HPA, HPG, HPT, gut–brain axis, neuroimmune axis, circadian system);</div> <div>• Clinical evidence supporting nutritional modulation in autoimmune, hormonal, neurological, psychiatric, metabolic, and autonomic disorders;</div> <div>• A narrative systematic review linking nutrients, bioactive compounds, and metabolic–neuroendocrine pathways;</div> <div>• Future perspectives for clinical practice, research, and translational applications.</div> <div> </div> <div>This is the first scientific manuscript to formally describe Neuroendocrine Nutrition as an applied, integrative model aimed at restoring biochemical communication between the body and the brain.</div>