Nano mesoporous silica as an efficient catalyst for the preparation of 2H- indazolo[2,1-b]phthalazin-triones under solvent-free condition

A nano mesoporous material designated as KIT-1 with interconnecting wormlike channels in a three dimensional disordered network with uniform pore size and high surface area. The network like channel structure of the present material gives an advantage for preventing channel blockage over the linear channel in MCM-41. The KIT-1 has also remarkable hydrothermal stability. KIT-1 as an efficient and reusable heterogeneous catalyst have been used for the preparation of 2H-indazolo[2,1-b]phthalazin-1,6,11(13H)-triones derivatives from the three-component condensation reaction. The method involves the reaction of various aromatic aldehydes, phthalhydrazide and dimedon, under solvent-free conditions. High yields, short reaction times and easy work-up are some advantages of this work.