Introduction of a nanocomposite of NiO/MgO for the regioselective synthesis of 1,4-disubstituted- 1,2,3-triazoles and investigation of antimicrobial properties

In this research, an eco-friendly procedure is reported for the synthesis of NiO/MgO nanocomposite by the co-precipitation method. The obtained nanocomposite was characterized using FE-SEM, EDS, BET, XRD, and TGA analyses. The catalytic performance of the NiO/MgO nanocomposite was investigated in the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles under mild conditions. The results revealed that the desired triazole derivatives were produced in high yields with excellent selectivity. The catalyst exhibited notable stability and recyclability over several cycles without significant loss of activity. In addition, the antibacterial activity of the NiO/MgO nanocomposite was evaluated against various bacterial strains, showing good inhibitory effects against the tested pathogens.