Study of Electrochemical Behavior of Drug Interaction Between Azithromycin and Hydroxychloroquine on Carbon Paste Modified Metal Film Electrode and Local Clay

In this study, a carbon graphite-clay paste electrode (CPEA) was proposed to study the electrochemical behavior of drugs such as azithromycin (AZI) and hydroxychloroquine (HYC). The electrochemical analysis was carried out by cyclic voltammetry (VC) in the potential range [-0.03; 0.35 V], in a phosphate buffer solution (0.1 M; pH = 6.4). It is in this logic that before the elaboration of the carbon graphite-clay composite, the clay powder was prepared and its structural and textural properties were examined by X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM). The results indicate that the electrode was effectively modified. The electrode was then subjected to electroanalysis at the same concentrations (3 mM) for individual and combined AZI, HYC, and AZI+HYC. However, in the presence of analyte, the phenomena are irreversible, with oxidation phenomena dominating. The electroactivity of the drugs used concerns the hydroxyl groups, observed around 0.18 V. Furthermore, an interaction study in the analytical application was conducted and it was found that the electroanalytical method used can be well adopted for the simultaneous electrochemical detection of HYC and AZI.