LAMA1 derived from colorectal cancer promotes M2 polarization in macrophages via activation of EGFR/AKT/CREB pathway

As a pro-carcinogenic factor released by CRC cells, LAMA1 affects the activation of the EGFR/AKT/CREB pathway in macrophages, causing M2 polarization and aggravating the malignant evolution of CRC.

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Publication Details

Journal
Central European Journal of Immunology
Published
2025-10-20
DOI
https://doi.org/10.5114/ceji.2025.154516
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

LAMA1 derived from colorectal cancer promotes M2 polarization in macrophages via activation of EGFR/AKT/CREB pathway

Central European Journal of Immunology
Immune cells in cancer
article

LAMA1 derived from colorectal cancer promotes M2 polarization in macrophages via activation of EGFR/AKT/CREB pathway

article en

Abstract

As a pro-carcinogenic factor released by CRC cells, LAMA1 affects the activation of the EGFR/AKT/CREB pathway in macrophages, causing M2 polarization and aggravating the malignant evolution of CRC.

Central European Journal of ImmunologyVol. 50(3)
Jinhua Central Hospital (CN)
Good health and well-being
Openalex Percentile: Top 41%
Immune cells in cancer
DOIOpen Access PDFOpenAlex
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LAMA1 derived from colorectal cancer promotes M2 polarization in macrophages via activation of EGFR/AKT/CREB pathway · Central European Journal of Immunology (2025) | TGRS Research Map | TGRS