ASSOCIATION OF INSULIN RESISTANCE WITH POLYCYSTIC OVARY SYNDROME

Background: Polycystic ovary syndrome (PCOS), a reproductive endocrine disorder with quintessential features of metabolic dysfunction, affects millions of women worldwide. Insulin resistance and hyperinsulinemia are common findings in women with polycystic ovary syndrome (PCOS). In insulin-resistant individuals, hyperinsulinemia is a key compensatory mechanism, aimed at maintaining glucose homeostasis. Objective: This study was undertaken to determine the association of hyperinsulinemia and insulin resistance with nonobese PCOS women. Methods: A cross sectional study was conducted in the department of Biochemistry and Molecular Biology, BIRDEM Academy, Shahbag, Dhaka, from July 2017 to June 2018. According to selection criteria total 83 women of 17 to 36 years of age were selected from the outpatient department of Obstetrics and Gynecology, BIRDEM-2 General Hospital. Among them 53 were women with established PCOS and 30 were age and BMI matched non PCOS women. In all the subjects, concentrations of fasting plasma glucose, serum insulin, HOMA-IR were estimated. Results: The mean concentrations of serum insulin (30.47±17.01 vs. 13.27±4.80; p<0.001) and HOMA-IR (8.41±6.28 vs. 3.22±1.01; p<0.001), were significantly increased in women with polycystic ovary syndrome when compared with non PCOS women. Frequency distribution of insulin sensitive and insulin resistant PCOS patients showed 71.7% insulin resistant and 28.3% insulin sensitive. In this study PCOS women were highly associated with insulin resistance than non PCOS women, which was statistically significant (71.7% vs. 13.3%, χ2=26.11, p<0.001). Multiple linear regression analysis revealed that PCOS was independently significant with HOMA-IR. But BMI and waist hip ratio were not significant with HOMA-IR. Conclusion: This study concluded that hyperinsulinemia and insulin resistance are associated with nonobese PCOS women.