RP‑HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF NARATRIPTAN AND NAPROXEN IN TABLET DOSAGE FORM

A simple, precise, and accurate reverse‑phase high‑performance liquid chromatography (RP‑HPLC) method was developed and validated for the simultaneous estimation of Naratriptan and Naproxen in combined tablet formulations. Chromatographic separation was achieved on a C18 column (150 × 4.6 mm, 5 µm) using an isocratic mobile phase containing phosphate buffer (pH adjusted with orthophosphoric acid) and acetonitrile in an optimized ratio. The flow rate, detection wavelength, and injection volume were selected to yield symmetrical, well‑resolved peaks for both analytes. Linearity was confirmed within defined concentration ranges, showing correlation coefficients greater than 0.999. The method exhibited high precision (%RSD < 2), accuracy (recovery 98–102 %), and robustness under minor variations of chromatographic parameters. The results confirm that the developed RP‑HPLC method is reliable and suitable for routine quality control of Naratriptan and Naproxen in pharmaceutical dosage forms. Keywords: Naproxen, RP‑HPLC, Validation, Linearity, Accuracy, Robustness.