PROTECTIVE EFFECTS OF AVOCADO PEAR SEED EXTRACT ON ETHYLENE GLYCOL INDUCED HEPATOTOXICITY IN WISTAR RATS

The current study was designed to evaluate the possible preventive effects of avocado pear seed ethanolic extracts (ASE) on ethylene glycol (EG) induced hepatotoxicity in Wistar rats. In this study, twenty five male wistar rats were used and divided into five groups of five wistar rats each; a normal control group, a positive control group treated with 0.1ml/kg b.w ethylene glycol only for seven days, two groups treated with different doses of avocado pear seed extract (100mg/kg b.w and 200mg/kg b.w morning and evening respectively) for 21 days and 0.1ml/kg b.w ethylene glycol for 7 days with continuous administration of the treatment dosage and the fifth group treated with 0.2mg/kg b.w folic acid and 0.3mg/kg b.w thiamine (morning and evening) and 0.1ml/kg b.w ethylene glycol for 7 days with continuous administration of the treatment dosage. Ethylene glycol induced liver injury evidenced by histological alterations as well as significant increase of serum indicators of impaired liver function including AST, ALT, ALP, GGT and Bilirubin. Antioxidant activities of superoxide dismutase, glutathione peroxidase and Catalase were significantly declined in the liver as a result of ethylene glycol administrations. Treatment with ethanolic extracts of Avocado pear seed significantly reduced the effect of ethylene glycol induced biochemical and histopathological deleterious alterations; \implying the extract reduced toxic effects of ethylene glycol and has potential to stabilize cell membranes and protect the cell /tissues from more damage.