VIEWPOINTS ON CUTANEOUS AGING AND NEW REJUVENATION STRATEGIES

The human skin undergoes an inevitable process of aging, prompted by both intrinsic (genetic) mechanisms and extrinsic (environmental) influences. Aged skin appears thin, dry, roughened with fine and coarse wrinkles and loss of elasticity. Histological changes include, thinning of epidermis and flattening of dermal epidermal junction due to effacement of rete ridges, together with fragmentation of dermal collagen matrix and less fibroblasts impairing dermal structural integrity. Skin aging has its social impact and that aroused the competitions of antiaging therapies to maintain the youthful appearance. Numerous approaches have been developed to slow down cutaneous aging process or to revitalize the youthfulness. In this review, changes occurring during skin aging with research advances on the use of some new trends of non-surgical skin rejuvenation strategies including snail slime, platelet rich plasma (PRP) alone and when combined with hyaluronic acid and stem cells are discussed emphasizing results from preclinical and clinical studies.