Seroprevalence and Clinical Correlates of Dengue Virus Infection in Daman, Union Territory, India: A Comparative Analysis with Regional and Global Studies

Abstract: Dengue virus (DENV) is one of the fastest spreading arboviral infections worldwide, with recurrent outbreaks in tropical and subtropical countries. India has seen a considerable high in dengue cases over the past two decades, often overlapping clinically with other endemic infections such as malaria and viral hepatitis. Despite growing evidence from larger cities, smaller districts like Daman remain understudied. This study focus to determine the seroprevalence and clinical correlates of dengue virus infection in Daman district, India, using NS1 antigen, IgM/IgG ELISA, and to compare findings with national and international reports to contextualize local epidemiology. Methodology: A cross-sectional study was carried out from November 2023 to November 2024 among 3,731 clinically suspected dengue cases in Daman. Samples were watched for NS1 antigen and dengue-specific antibodies using ELISA; demographic, clinical, and haematological parameters were analysed. A narrative review of seven peer-reviewed studies from India (Bhopal, Daman, Kalaburagi, Bidar, Ahmedabad, Saurashtra) and Taiwan was undertaken to evaluate geographic variations in seroprevalence, diagnostic techniques, and clinical outcomes. Dengue seropositivity rate was 13.8% (513/3,731). Males counted for 63% of cases, and the 21–30-year age group was most affected (45%). Rural residents’ area made up 78% of positive cases. Headache and myalgia were significantly associated with NS1 positivity (p < 0.001). serious thrombocytopenia (<50,000/µL) was observed in 13% of cases, while 40% had moderate reductions. Seasonal high peak shown from August to October. Co-infection with hepatitis B in Bhopal, secondary infections in Karnataka, and increased vulnerability among the elderly during Taiwan’s epidemic. Keywords: Dengue, seroprevalence, NS1 antigen, ELISA, Daman, clinical features. Title: Seroprevalence and Clinical Correlates of Dengue Virus Infection in Daman, Union Territory, India: A Comparative Analysis with Regional and Global Studies Author: Abhishek Amrutlal Vaishya, Dr. Himani Goyal Sharma, Dhanji Rajani International Journal of Novel Research in Life Sciences ISSN 2394-966X Vol. 12, Issue 6, November 2025 – December 2025 Page No: 1-9 Novelty Journals Website: www.noveltyjournals.com Published Date: 05-November-2025 DOI: https://doi.org/10.5281/zenodo.17530399 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/Seroprevalence%20and%20Clinical%20Correlates-05112025-1.pdf