Needleless Self-Administration of Vaccines via Mucosal (Rectal) Thermo-/Mucoadhesive Gels: A Mathematical, Biological, and Chemical Overview

This report provides a theoretical framework for the needleless self-administration of vaccines through the rectal mucosa using thermo- and mucoadhesive gel carriers. It evaluates how existing liquid vaccine formulations could be integrated into a biocompatible gel to enable controlled antigen transport across the mucus and epithelial layers. The document develops mathematical transport models, rheological relationships, and simplified immune-response dynamics to explore feasibility. It also outlines representative categories of materials and non-specific equipment relevant to early concept development. No operational procedures, dosages, or fabrication instructions are provided. The purpose of the report is to support conceptual analysis, parameter selection, and early modeling studies while maintaining safety and compliance constraints.