Effect of Cyanoacrylate Microbial Sealant on Intraoperative Bacterial Contamination in Spine Surgery: A Prospective Consecutive Study

Introduction: Surgical site infection (SSI) remains a significant complication in spinal surgery, particularly in instrumented procedures. While modern skin antisepsis and antibiotic prophylaxis reduce infection risk, microbial ingress from residual skin flora persists. Cyanoacrylate-based microbial sealants have shown promise in other surgical fields, but their efficacy in spinal surgery remains unclear. This study aimed to evaluate whether a cyanoacrylate microbial sealant could reduce postoperative drain colonization, an established surrogate marker for early bacterial contamination.