Research Progress on the Regulation of Glycolysis in Gastric Cancer: Key Genes and Enzymes

Zihao Chen,1,* Jiangyu Li,2,* Hongping Ju,2 Man Yang,2 Ting Zhao3 1Department of Surgical Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; 2School of Medicine, Kunming University, Kunming, People’s Republic of China; 3Department of Clinical Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting Zhao, Department of Clinical Pharmacy, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, People’s Republic of China, Email [email protected]: Gastric cancer (GC) is a malignant tumor with extremely high morbidity and mortality. The incidence of GC in China is second only to that of lung cancer, seriously threatening human health and safety. Glycolysis is one of the important ways for cells to obtain energy and most tumor cells also rely on aerobic glycolysis, which plays a key role in the occurrence and development of GC. This article aims to systematically summarize the effects of key glycolytic enzymes and their upstream regulatory genes on GC, to provide a basis for revealing the pathogenesis of GC, and to evaluate potential therapeutic targets for GC.Keywords: gastric cancer, glycolysis, gene regulation, enzyme regulation