A regularized Cox model for selecting interactions and time-varying covariate effects

Introduction: The Cox proportional hazards model is a widely used method for analyzing clinical time-to-event data. The basic form of the model assumes the covariate effects on the hazard function to be constant over time. However, in many clinical settings, covariate effects may vary with time, and [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2025-11-03
DOI
https://doi.org/10.3205/25gmds083
Primary Topic
Statistical Methods and Inference
Type
article
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article

A regularized Cox model for selecting interactions and time-varying covariate effects

German Medical Science (German Research Foundation)
Statistical Methods and Inference
article

A regularized Cox model for selecting interactions and time-varying covariate effects

article en

Abstract

Introduction: The Cox proportional hazards model is a widely used method for analyzing clinical time-to-event data. The basic form of the model assumes the covariate effects on the hazard function to be constant over time. However, in many clinical settings, covariate effects may vary with time, and [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
Koblenz University of Applied Sciences (DE), University Hospital Bonn (DE), Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
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Statistical Methods and Inference
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