Leveraging a genetic proxy to investigate the effects of lifelong cardiac sodium channel blockade

Introduction: Cardiac arrhythmias, most notably atrial fibrillation (AFib), pose a significant global health burden with limited preventive strategies. The SCN5A gene, encoding the cardiac sodium channel Nav1.5, is crucial for heart rhythm, with variants linked to various arrhythmias. The Finnish-enriched [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2025-11-03
DOI
https://doi.org/10.3205/25gmds003
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
0.00
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article

Leveraging a genetic proxy to investigate the effects of lifelong cardiac sodium channel blockade

German Medical Science (German Research Foundation)
Cardiac electrophysiology and arrhythmias
article

Leveraging a genetic proxy to investigate the effects of lifelong cardiac sodium channel blockade

article en

Abstract

Introduction: Cardiac arrhythmias, most notably atrial fibrillation (AFib), pose a significant global health burden with limited preventive strategies. The SCN5A gene, encoding the cardiac sodium channel Nav1.5, is crucial for heart rhythm, with variants linked to various arrhythmias. The Finnish-enriched [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
Broad Institute (US), Hasso Plattner Institute (DE), Finnish Institute for Health and Welfare (FI), Amsterdam University Medical Centers (NL), University of Amsterdam (NL)
Openalex Percentile: Top 35%
Cardiac electrophysiology and arrhythmias
DOIOpen Access PDFOpenAlex
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