Methods for Analyzing Multiple Time-to-Event Endpoints in Randomized Clinical Trials: A Comprehensive Overview

Introduction: In clinical trials, time-to-event analyses are essential for evaluating treatment efficacy and understanding patient outcomes. Traditional methods such as the Cox proportional hazards model or Kaplan-Meier estimation typically focus on time-to-first events. However, this approach may overlook [for full text, please go to the a.m. URL]