Evaluation of surrogate validation approaches accepted in German health technology assessment

Introduction: Surrogate variables are crucial in drug development, substituting endpoints that are difficult or time-consuming to collect. A frequent example is progression-free survival (PFS) as a surrogate for overall survival (OS). Among Health Technology Assessment (HTA) bodies in Europe, only the [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2025-11-03
DOI
https://doi.org/10.3205/25gmds035
Primary Topic
Health Systems, Economic Evaluations, Quality of Life
Type
article
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article

Evaluation of surrogate validation approaches accepted in German health technology assessment

German Medical Science (German Research Foundation)
Health Systems, Economic Evaluations, Quality of Life
article

Evaluation of surrogate validation approaches accepted in German health technology assessment

article en

Abstract

Introduction: Surrogate variables are crucial in drug development, substituting endpoints that are difficult or time-consuming to collect. A frequent example is progression-free survival (PFS) as a surrogate for overall survival (OS). Among Health Technology Assessment (HTA) bodies in Europe, only the [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
Boehringer Ingelheim (Germany) (DE)
Good health and well-being
Openalex Percentile: Top 30%
Health Systems, Economic Evaluations, Quality of Life
DOIOpen Access PDFOpenAlex
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Evaluation of surrogate validation approaches accepted in German health technology assessment · German Medical Science (German Research Foundation) (2025) | TGRS Research Map | TGRS