Multimodal Targeted Therapy Hypothesis for Prion Diseases: Integrating Enzymatic Degradation, Lysosomal Activation, Focused-Energy Disruption, and Na⁺/K⁺-ATPase Pathway Modulation

This research proposal by Orhan Mete Gürbüz (MD Student, European University Georgia) presents a novel multimodal therapeutic hypothesis for prion diseases. The proposed model integrates Na⁺/K⁺-ATPase pathway modulation, enzymatic degradation of misfolded PrPˢᶜ aggregates, focused-energy disruption via high-intensity focused ultrasound (HIFU), and lysosomal-autophagy activation. The combination aims to achieve synergistic prion clearance and neuroprotection. This conceptual framework merges molecular neuroscience, bioengineering, and energy-assisted medicine to propose a potential paradigm shift in neurodegenerative disease therapy.