Necrólisis epidérmica tóxica inducida por fármacos antiepilépticos y su manejo. Un informe de caso

Toxic Epidermal Necrolysis (TEN) is a rare and potentially life-threatening dermatological emergency characterized by widespread epidermal detachment and mucosal involvement, associated with significant morbidity and mortality. Early diagnosis and treatment are imperative to improving patient outcomes.This case report presents the clinical course, management, and outcomes of a patient diagnosed with TEN. A 29-year-old female with a history of polypharmacy and medication allergies presented with a sudden onset of fever, malaise, and a diffuse rash. A thorough examination revealed extensive epidermal detachment involving more than 80% of the body surface area, including mucosal involvement. Carbamazepine, identified as the suspected causative agent, had been administered recently. The patient was promptly admitted to the intensive care unit for specialized care, including supportive measures, wound care, and close monitoring of fluid and electrolyte balance. Intravenous immunoglobulin therapy was initiated, along with a multidisciplinary approach involving dermatology, ophthalmology, and nutrition support. The patient's condition gradually improved over several weeks, with re-epithelialization of the affected areas and resolution of systemic symptoms.This case highlighted the importance of early diagnosis, prompt management, and a multidisciplinary approach in optimizing outcomes of this disease. As this is a rare disease, there are no prospective studies, no Immuno-genetic biomarkers, and not enough randomized controlled trials. further research in these areas may provide valuable insights into the management of this disease.