A new therapeutic target for osteoporosis: Arcyriaflavin A as a CDK4 inhibitor suppressing osteoclastogenesis

Objectives and questions: Macrophage polarization influences osteoclast differentiation, a process regulated by the JAK-STAT3 pathway. CDK4 inhibits this pathway by preventing STAT3 activation. We identified Arcyriaflavin A (ArcyA), an indole-based compound, as a natural CDK4 inhibitor and investigated [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2025-10-31
DOI
https://doi.org/10.3205/25dkou195
Primary Topic
Bone Metabolism and Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

A new therapeutic target for osteoporosis: Arcyriaflavin A as a CDK4 inhibitor suppressing osteoclastogenesis

German Medical Science (German Research Foundation)
Bone Metabolism and Diseases
article

A new therapeutic target for osteoporosis: Arcyriaflavin A as a CDK4 inhibitor suppressing osteoclastogenesis

article en

Abstract

Objectives and questions: Macrophage polarization influences osteoclast differentiation, a process regulated by the JAK-STAT3 pathway. CDK4 inhibits this pathway by preventing STAT3 activation. We identified Arcyriaflavin A (ArcyA), an indole-based compound, as a natural CDK4 inhibitor and investigated [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
Shanxi Medical University (CN), University Hospital Bonn (DE), Universitätsklinikum Knappschaftskrankenhaus Bochum (DE), Second Hospital of Shanxi Medical University (CN), Ruhr University Bochum (DE)
Openalex Percentile: Top 43%
Bone Metabolism and Diseases
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