Exploring innovative strategies to enhance osteoporotic lumbar fusion: Efficacy of local delivery of prostaglandin EP4 receptor agonist KMN-159 and zoledronic acid in a rat model

Objectives and questions: Spinal fusion in patients with osteoporosis is challenging [ref:1]. rhBMP-2 is the only FDA-approved osteoinductive agent but has high costs and side effects [ref:2]. KMN-159, a novel prostaglandin EP4 receptor agonist, promotes spinal fusion in healthy [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2025-10-31
DOI
https://doi.org/10.3205/25dkou275
Primary Topic
Spine and Intervertebral Disc Pathology
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploring innovative strategies to enhance osteoporotic lumbar fusion: Efficacy of local delivery of prostaglandin EP4 receptor agonist KMN-159 and zoledronic acid in a rat model

German Medical Science (German Research Foundation)
Spine and Intervertebral Disc Pathology
article

Exploring innovative strategies to enhance osteoporotic lumbar fusion: Efficacy of local delivery of prostaglandin EP4 receptor agonist KMN-159 and zoledronic acid in a rat model

article en

Abstract

Objectives and questions: Spinal fusion in patients with osteoporosis is challenging [ref:1]. rhBMP-2 is the only FDA-approved osteoinductive agent but has high costs and side effects [ref:2]. KMN-159, a novel prostaglandin EP4 receptor agonist, promotes spinal fusion in healthy [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
University Hospital Carl Gustav Carus (DE)
Openalex Percentile: Top 35%
Spine and Intervertebral Disc Pathology
DOIOpen Access PDFOpenAlex
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Exploring innovative strategies to enhance osteoporotic lumbar fusion: Efficacy of local delivery of prostaglandin EP4 receptor agonist KMN-159 and zoledronic acid in a rat model · German Medical Science (German Research Foundation) (2025) | TGRS Research Map | TGRS