Spontaneous resolution of dengue maculopathy in an human immunodeficiency virus-infected individual

Dengue maculopathy exhibits numerous clinical phenotypes, including foveolitis and outer maculopathy, which involve both ischemic and inflammatory mechanisms.[1] A 36-year-old male patient being treated for high fever (dengue immunoglobulin M positive) was subsequently diagnosed as human immunodeficiency virus infected with a low CD4 count (71 cells/mm3). Seven days postdischarge, blurred vision was noted in the right eye (6/12, N6). Ophthalmoscopy revealed an orangish macular lesion [Figure 1a], and a baseline optical coherence tomography (OCT) revealed a dengue outer maculopathy with hyporeflective, thickened outer retinal layers with subretinal edema [Figure 1b]. He was treated conservatively, and a spontaneous resolution was seen 15 days later with a normal-looking fundus and normal OCT [Figure 1c and d].Figure 1: (a) Fundus photo of the right eye showing an orangish macular lesion. (b) A baseline optical coherence tomography (OCT) revealing a dengue outer maculopathy with hyporeflective, thickened outer retinal layers with subretinal edema. (c) Fundus photo after 15 days revealing spontaneous resolution. (d) OCT is confirmatory of resolutionData availability statement The author had full access to all the data in this report and takes responsibility for the same. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

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Publication Details

Journal
Journal of Clinical Ophthalmology and Research
Published
2025-10-01
DOI
https://doi.org/10.4103/jcor.jcor_216_25
Primary Topic
Mosquito-borne diseases and control
Type
article
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article

Spontaneous resolution of dengue maculopathy in an human immunodeficiency virus-infected individual

Journal of Clinical Ophthalmology and Research
Mosquito-borne diseases and control
article

Spontaneous resolution of dengue maculopathy in an human immunodeficiency virus-infected individual

article en

Abstract

Dengue maculopathy exhibits numerous clinical phenotypes, including foveolitis and outer maculopathy, which involve both ischemic and inflammatory mechanisms.[1] A 36-year-old male patient being treated for high fever (dengue immunoglobulin M positive) was subsequently diagnosed as human immunodeficiency virus infected with a low CD4 count (71 cells/mm3). Seven days postdischarge, blurred vision was noted in the right eye (6/12, N6). Ophthalmoscopy revealed an orangish macular lesion [Figure 1a], and a baseline optical coherence tomography (OCT) revealed a dengue outer maculopathy with hyporeflective, thickened outer retinal layers with subretinal edema [Figure 1b]. He was treated conservatively, and a spontaneous resolution was seen 15 days later with a normal-looking fundus and normal OCT [Figure 1c and d].Figure 1: (a) Fundus photo of the right eye showing an orangish macular lesion. (b) A baseline optical coherence tomography (OCT) revealing a dengue outer maculopathy with hyporeflective, thickened outer retinal layers with subretinal edema. (c) Fundus photo after 15 days revealing spontaneous resolution. (d) OCT is confirmatory of resolutionData availability statement The author had full access to all the data in this report and takes responsibility for the same. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

Journal of Clinical Ophthalmology and ResearchVol. 13(4)
Lilavati Hospital & Research Centre (IN)
Good health and well-being
Openalex Percentile: Top 34%
Mosquito-borne diseases and control
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Spontaneous resolution of dengue maculopathy in an human immunodeficiency virus-infected individual · Journal of Clinical Ophthalmology and Research (2025) | TGRS Research Map | TGRS