Association between macrophage inflammatory protein-1β and prognosis of patients with sepsis

Objective: To evaluate the association between serum levels of macrophage inflammatory protein-1β (MIP-1β) and disease severity as well as 28-day mortality in sepsis patients. Methods: The retrospective study included adult patients with sepsis who were admitted to the emergency department. Demographic characteristics and laboratory parameters measured within 3 hours of admission were compared, including MIP-1β, lactate, procalcitonin, C-reactive protein, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and Sequential Organ Failure Assessment score. Results: The study included a total of 202 sepsis patients, who were stratified by 28-day outcomes into 61 survivors and 141 non-survivors. MIP-1β levels were significantly higher in the non-survivor group [(196.08±10.75) pg/mL] than in the survivor group [(125.48±4.70) pg/mL, P <.05]. The areas under the receiver operating characteristic curves (AUC) for predicting 28-day mortality were 0.712 for MIP-1β, 0.599 for lactate, and 0.766 for APACHE II score. MIP-1β levels showed a positive correlation with lactate ( r =0.172). Binary logistic regression identified MIP-1β ( OR =1.02, 95% CI : 1.01-1.03, P =.001), APACHE II score ( OR =1.16, 95% CI : 1.08-1.24, P <.001), and lactate ( OR =1.45, 95% CI : 1.08-1.95, P =.01) as independent risk factors for 28-day mortality in sepsis patients. Conclusions: MIP-1β demonstrates high sensitivity and specificity in predicting poor outcomes in sepsis. MIP-1β, APACHE II score, and lactate are independent risk factors for 28-day mortality in these patients.