Biologics for Moderate to Severe Asthma in Children From the department of Paediatrics at Masaka Regional Referral Hospital, UGANDA: A case series

Biologic therapies play a significant role in reducing exacerbations, hospitalizations and the need for maintenance systemic steroids, while also improving the quality of life in patients with severe asthma. The evidence for their clinical efficacy comes from randomised controlled trials (RCTs), extension studies, metanalyses and real-world data.Biologics offer significant benefits for managing severe asthma, particularly for individuals with type 2 inflammation, by reducing exacerbations, improving lung function, and enhancing quality of life, according to the ERS. These medications target specific inflammatory pathways involved in asthma, leading to improved control and reduced reliance on oral corticosteroids.