Formulation and Characterization of Minoxidil Oral Thin Film

Objective: The primary aim of the current investigation was to formulate and assess immediate-release oral thin films of minoxidil, with the goal of increasing the bioavailability of the medication and accelerating its onset of action, thereby enhancing patient adherence. Methods: Using a film-forming polymer such as hydroxypropyl methylcellulose, the solvent evaporation method was used to create instantrelease oral thin films of minoxidil. Results: A number of physicochemical characteristics, such as drug content, in vitro drug release, folding endurance, tensile strength, thickness and weight change, were assessed for the films. Since the formed films F1-F9 were immediately wetted by the dissolving medium, no variations in the in vitro dissolution of the drug were observed. For the F8 formulations, the drug release was almost 94%. Conclusion: The current formulation uses mouth-dissolved films that have a quick start of action to deliver medication properly and have good therapeutic efficacy when taken orally.