A COMPARATIVE LITERARY, ANALYTICAL, PHARMACOLOGICAL AND CLINICAL EVALUATION OF 500 MG POLYHERBAL FORMULATION CAPSULE FOR DIABETES MANAGEMENT; PHYTOCHEMICAL PROFILING, MECHANISTIC INSIGHTS, AND THERAPEUTIC EFFICACY

Understanding Diabetes Mellitus and Its Ayurvedic Perspective Diabetes Mellitus has been recognized as a major health issue since ancient times, affecting people across all regions and civilizations. It is a complex metabolic disorder characterized by persistently elevated blood sugar levels, which occur either due to insufficient insulin production, resistance to insulin, or a combination of both. In today’s world, the number of people living with diabetes has risen dramatically—largely driven by modern sedentary lifestyles and unhealthy dietary habits. In Ayurveda, this condition is identified as “Madhumeha,” a specific form of “Prameha.” It arises from an imbalance in the Kapha dosha, disturbances in Medo dhatu (fat metabolism), and a weakened Agni (digestive fire). These internal disruptions slow down the body’s metabolic processes, ultimately paving the way for disease. By viewing Madhumeha through the Ayurvedic lens, one gains a more holistic and integrative understanding of both its root causes and its management.