Integrated Platform for Assessing the Quality of Macromolecular Models

Macromolecular models are crucial for biomedical research, particularly in drug discovery. However, variations in model quality can impact the reliability of downstream analyses [1, 2]. To advance the evaluation of macromolecular structures, we developed an integrated system for the rapid exploration and comparison of protein structure models derived from cryoEM and crystallography experiments. Our platform seamlessly incorporates multiple resources, including RCSB PDB [3], PDBe [4], PDBj [5], UniProt [6], PDB-REDO [7, 8], EMDB [9], and AlphaFold DB [10]. Currently, the system operates within the PyMOL 3.1 ecosystem, providing an efficient and streamlined workflow for structural analysis.