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The giant impact of synapses on brain function and diseaseConfocal images from a young adult (left) and aged (right) mouse neuromuscular junction displaying increased degeneration and a reduced number of release sites.Postsynaptic acetylcholine receptors are labelled with fluorescently tagged -bungarotoxin (magenta) and presynaptic neurotransmitter release sites are visualized by immunolabeling of the active zone-specific protein piccolo (green puncta).See Li et al. pp