Red Grape Seed Extract for Memory Enhancement in Alzheimer’s Disease in Rats with Reference to the Glutamate Metabolism

Background: Free radicals and oxidative stress are the causes of Alzheimer's dementia, a neurodegenerative condition. Antioxidants can prevent Alzheimer's disease and improve memory. Red grape seeds have demonstrated the ability to enhance cognition in rats afflicted with Alzheimer’s disease due to their antioxidant properties. Materials and Procedures: Male rats were IP-infused with 120mg/kg body weight of D-galactose to create an Alzheimer's model. On days 30 and 60, biochemical parameters were assessed. Results: We found that the levels of several biomarkers, including glutamine content, glutamine synthetase, glutamate dehydrogenase, and glutaminase activity, had significantly improved. Conclusions: Based on our findings, red grape seeds may contain active components that can help treat and prevent cognitive deficits associated with Alzheimer's disease.