Salivary Redox Biomarkers as a Non-Invasive Screening Tool for Early Detection of Sudden Unexplained Cardiac Death Risk in Young Healthy Individuals

Concept Summary The proposed project aims to innovate a non-invasive salivary biomarker platform for early detection of hidden cardiac risk in apparently healthy young individuals. By evaluating enzymatic antioxidants (SOD, CAT, GPx) and lipid peroxidation products (MDA), saliva can serve as an accessible diagnostic fluid to detect oxidative stress–induced cardiac vulnerability before clinical manifestation. Novelty and Innovation First to propose saliva as a primary screening matrix for SUCD risk assessment. Introduces the “Salivary Redoxome” as a systems-level diagnostic concept. Bridges basic redox biology with preventive cardiology and public health. Potential to develop a rapid biosensor or point-of-care diagnostic tool. Potential Applications 1. Population-level screening for young adults, students, and athletes. 2. Integration into sports medicine and occupational health programs. 3. Development of saliva-based diagnostic kits or wearables. 4. Research on redox-genetic interactions in sudden cardiac death. Future Development Plan 1. Analytical validation of SOD, CAT, GPx, and MDA assays in saliva. 2. Correlation with ECG findings and genetic susceptibility (RyR2, KCNQ1, SCN5A). 3. Prototype design of a lab-on-chip redox biosensor. 4. Clinical trials and global standardization of the Salivary Redox Screening Tool. Confidentiality and Ownership Notice This document contains proprietary scientific concepts and intellectual property developed by Dr. Ahmed Adel Mansour Kamar.Unauthorized use, duplication, or disclosure of this information without written consent from the inventor is strictly prohibited.